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The MRC has come together with seven other research funders to create an interactive ‘map’ of the funding schemes available to biomedical researchers. The first of its kind focused on medical research, the ‘funding view’ takes the form of an interactive map, giving the user an easy way to navigate the UK biomedical research funding...
The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Research at Leeds has shown how single domain antibodies can be used to characterize the regulatory mechanisms of kinases and provide a rational basis for structure-guided design of...
Novel models for anti-Toxoplasma gondii drug discovery Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Research at Leeds has developed novel models to facilitate drug development and used these models to envision, and then create, novel 4-(1H)-quinolone...