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An unusual inactive kinase conformation identified

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A series of  kinase inhibitors was discovered to allosterically inhibit the endoribonuclease function of the dual kinase-endoribonuclease inositol-requiring enzyme 1 alpha (IRE1 alpha), a key component of the unfolded protein response in mammalian cells and a potential drug target in multiple human diseases. Inhibitor optimization gave compounds with high kinome selectivity that prevented endoplasmic reticulum stress-induced IRE1 alpha oligomerization...

New platform could transform protein research

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A new platform for photoinduced-crosslinking could transform protein research. Leading academics at the Astbury Centre for Structural Molecular Biology have significantly advanced a method for studying the interactions of proteins, which they say should transform research in this area. Professor Sheena Radford, Director of the Centre, and a Fellow of the Royal Society, and colleague...

Overcoming the challenges of peptide simulations

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A new paper marks a step forward in our understanding of peptide fragments and methods for simulating them. Researchers from the Astbury Centre for Structural Molecular Biology and School of Chemistry have, for the first time, calculated the solubility diagram of amyloid β (16-22) peptide – a peptide fragment related to the onset of Alzheimer's...

New tool to find and fight the deadliest lymphomas

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UK scientists have found a new way to identify people with the most aggressive types of lymphoma, which are less likely to respond to standard drugs. Lymphomas are a form of cancer affecting white blood cells and although these tumours looked the same as others under the microscope, the new test – called gene expression profiling...

Astbury Centre researchers talking at Pint of Science

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Pub goers can pair their pint with the latest scientific research as the University of Leeds brings Pint of Science to city watering holes. Leeds is joining more than 100 cities around the world taking part in this global festival from 15-17 May. University of Leeds researchers will be speaking at six pubs across the...

Leeds University Be Curious festival returns

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Have you ever wondered what happens in a University? Ever been curious about the research done at the University of Leeds and what relevance it has to you and to the Leeds and Yorkshire area? Be Curious 2017 will be held at the University of Leeds, Parkinson building on Saturday 25 March 2017, 10am -...

Scientists prove new approach to Polio vaccines works

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Despite the success of vaccines produced from "virus-like particles" (VLPs) for hepatitis B and human papilloma viruses, poliovirus VLPs have proved to be too unstable to make practical vaccines. Now, a research team from the Faculty of Biological Sciences (FBS) has found a new way to modify these VLPs, also known as "empty capsids", by...