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Leeds research on a synthetic, protein, allosteric inhibitor of Aurora-A is the 2nd most read in Open Biology

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The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects.

Research at Leeds has shown how single domain antibodies can be used to characterize the regulatory mechanisms of kinases and provide a rational basis for structure-guided design of allosteric Aurora-A kinase inhibitors.